Toll-like receptor 7 contributes to neuropathic pain by activating NF-κB in primary sensory neurons
نویسندگان
چکیده
منابع مشابه
Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain
Primary sensory neurons in the DRG play an essential role in initiating pain by detecting painful stimuli in the periphery. Tissue injury can sensitize DRG neurons, causing heightened pain sensitivity, often leading to chronic pain. Despite the functional importance, how DRG neurons function at a population level is unclear due to the lack of suitable tools. Here we developed an imaging techniq...
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Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons, which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses gene expression. Here, we report that peripheral nerve injury increases expression of the DNA methyltransferase DNMT3a in the injured DRG neurons via the activation of the transcription factor octamer transcription fac...
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Increasing evidence suggests that neuro-immune and neuro-glial interactions are critically involved in chronic pain sensitization. It is well studied how immune/glial mediators sensitize pain, but how sensory neurons control neuroinflammation remains unclear. We employed Myd88 conditional knockout (CKO) mice, in which Myd88 was deleted in sodium channel subunit Nav1.8-expressing primary sensory...
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ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2020
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2020.03.019